interest is focused on questions relating to chromosome structure and function.
The research in Shanghai was focussed on:
We investigate the temporal and cell-specific changes in the expression of the transcription factor E2f. This protein has important regulatory during cell cycle progression and DNA replication. A mutant cause by the insertion of a P element into the E2f gene sheds new light on the tasks of E2f. We have repressed the function of E2F1 transcripts with RNAi methods. This repression shows inheritable epigenetic effects. We try to undertstand the mechnism of this process.
has become clear that micro-RNAs play important roles for chromatin structure
and might therefore also be involved in the regulation of epigenetic effects. We
have initiated a study of micro-RNAs in the male germ line of Drosophila which
may help understanding the epigenetic effects discribed before.
A publication summarizing various aspects of the earlier work of my laboratory:
in Drosophila. Eur J Cell Biology 40:167-176 (1996)
Akhmanova A, Miedema K, Wang Y, van Bruggen M, Berden JH, Moudrianakis EN, Hennig W The localization of histone H3.3 in germ line chromatin of Drosophila males as established with a histone H3.3-specific antiserum. Chromosoma 106:335-347 (1997)
Akhmanova A, Hennig W: A Drosophila melanogaster histone H2B retropseudogene is inserted into a region rich in transposable elements. Genome 41:396-401(1998)
Hennig W: Heterochromatin. Chromosoma 108:1-9 (1999) (Review)
Hennig W: The Revolution
of the Biology of the Genome. Cell Research 2003 (click
here to download)
Feng R, Tang X, Becker A, Berger A, Ye J, Akhmanova A, Hennig W: Regulation of the expression of histone H3.3 by differential polyadenylation. Genome (2005)
W. Hennig. Bioethics in China. EMBO Reports 7:850-854 (2006)
A. Weyrich, X. Tang, Guoliang X., C. Hunzinger, A. Schrattenholz, W. Hennig. Male germ line of Drosophila is not methylated. NCB (2008)
A.R. Gruber, C. Kilgus, A. Mosig, I.L. Hofacker, W. Hennig, P.F. Stadler. Arthropod 7SK RNA. Mol. Biol. Evol. Doi 10.1093/molev/nsu140
Research in China. Experiences from 23 years of
molecular genetics research in China. EMBO Reports 10, 545 (2009)
W. Hennig. Research in China. Experiences from 23 years of molecular genetics research in China. EMBO Reports 10, 545 (2009)
W. Hennig, A. Weyrich.
Histone modifications in the male germ line of Drosophila. BMC
Developmental Biology 13:7
(The background of these pages is a part of
a "Miller spread" of a Y chromosomal gene of Drosophila. Growing transcripts
are visualized with the aid of the electron microscope in my laboratory
by Ingrid Siegmund and Wolfgang Hennig)